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OBJECTIVE: To analyze the relationship between the cumulative noise exposure( CNE) and prevalence of hypertension in iron and steel production workers. METHODS: By convenience sampling method,2 253 workers,whose workplace in an iron and steel enterprise with wet bulb globe temperature index less than 25. 0 ℃,were selected as study subjects. The blood pressure and workplace noise exposure level were measured. According to the equal energy principle,the normalized continuous A-weighted sound pressure level equivalent to an 8 h-working-day and workers' length of service were used to calculate the CNE level. The workers with CNE≥75 d B( A) ·year were regarded as the exposure group,and those with CNE < 75 d B( A) ·year were deemed as the control group. RESULTS: The prevalence rate of hypertension in the exposure group was higher than that of the control group( 32. 3% vs 21. 5%,P < 0. 01). With the increased CNE level,the prevalence rate of hypertension increased( P < 0. 01). The multiple logistic regression analysis results showed that the prevalence risk of hypertension disputed an upward trend of the dose-response relationship following the increasing CNE among the iron and steel production workers( P < 0. 01) after controlling the confounding factors of age,body mass index,educational background,family history of hypertension,smoking,alcohol drinking,salt intake,fried barbecue food intake and so on. CONCLUSION: CNE is a vital factor which influences hypertension prevalence in iron and steel production workers. Strengthen the noise protection is helpful for the prevention and treatment of hypertension in the steel workers.
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OBJECTIVE: To analyze the relationship between the high-temperature working classification and prevalence of hypertension in iron and steel production workers. METHODS: By a convenience sampling method,2 798 workers in an iron and steel production enterprise were selected as study subjects. They were divided into high-temperature working group( 1 070 cases) and non-high-temperature working( control) group( 1 728 cases). The occupational health status was investigated by questionnaire survey and the blood pressure was measured. The wet bulb globe temperature in workplace of high temperature working group was measured,and the high-temperature classification was made based on the time of exposure to high temperature. RESULTS: The prevalence rate of hypertension of 2 798 iron and steel production workers was32. 8%. The prevalence rate of hypertension of high-temperature working group was higher than that of the control group( 41. 3% vs 27. 5%,P < 0. 01). The prevalence rate of hypertension in high temperature working group presented an increasing tendency with the increase of high-temperature working level( P < 0. 01). The multiple logistic regression analysis results showed that excluding the confounding factors of age,body mass index,family history of hypertension,educational background,smoking,alcohol drinking,salt intake and mental stress,it showed that high-temperature working classification was positively correlated with increasing prevalence of hypertension in high-temperature working group( P <0. 01); and the initial exposure age to high-temperature was negatively correlated with the prevalence of hypertension in iron and steel production workers( P < 0. 01). CONCLUSION: High-temperature is an important influence factor to the prevalence of hypertension in iron and steel production workers. Strengthening the management of high-temperature classification is helpful for the prevention and treatment control of hypertension in the iron and steel production workers
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<p><b>OBJECTIVE</b>To study the possible effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction (FGR), and to provide a basis for antepartum taurine supplementation to promote brain development in children with FGR.</p><p><b>METHODS</b>A total of 24 pregnant Sprague-Dawley rats were randomly divided into three groups: control, FGR, and taurine (n=8 each ). A rat model of FGR was established by food restriction throughout pregnancy. RT-PCR, immunohistochemistry, and Western blot were used to measure the expression of the specific intracellular markers for neural stem cells fatty acid binding protein 7 (FABP7), Rho-associated coiled-coil containing protein kinase 2 (ROCK2), ras homolog gene family, member A (RhoA), and Ras-related C3 botulinum toxin substrate (Rac).</p><p><b>RESULTS</b>The FGR group had significantly lower OD value of FABP7-positive cells and mRNA and protein expression of FABP7 than the control group, and the taurine group had significantly higher OD value of FABP7-positive cells and mRNA and protein expression of FABP7 than the FGR group (P<0.05). The FGR group had significantly higher mRNA expression of RhoA and ROCK2 than the control group. The taurine group had significantly higher mRNA expression of RhoA and ROCK2 than the control group and significantly lower expression than the FGR group (P<0.05). The FGR group had significantly lower mRNA expression of Rac than the control group. The taurine group had significantly higher mRNA expression of Rac than the FGR and control groups (P<0.05). The FGR group had significantly higher protein expression of RhoA and ROCK2 than the control group. The taurine group had significantly lower protein expression of RhoA and ROCK2 than the FGR group (P<0.05).</p><p><b>CONCLUSIONS</b>Antepartum taurine supplementation can promote the proliferation of neural stem cells in rats with FGR, and its mechanism may be related to the regulation of the activity of Rho family factors.</p>